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Image Search Results
Journal: Alzheimer's & Dementia
Article Title: Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort
doi: 10.1002/alz.14535
Figure Lengend Snippet: Scatter plots illustrate the inter‐platform comparisons between NULISAseq and other technologies. (A) Concordance between NULISAseq and Simoa for classical AD biomarkers. (B–C) Inter‐platform comparison between NULISAseq, Simoa, and Quest for TNF (B) and IL‐6 (C). NULISAseq biomarkers were quantified using NPQ, representing the log2‐transformation of normalized target counts. The abundance units are pg/mL for Simoa and Quest immunoassays. Rho and p ‐values were determined using Spearman rank‐based correlation. Red lines indicate least‐squares regression lines. Statistical significance is denoted as follows: * p < 0.05, ** p < 0.01, *** p < 0.001. Aβ, amyloid beta; AD, Alzheimer's disease; NPQ, NULISA protein quantification; NULISA, NUcleic acid Linked Immuno‐Sandwich Assay; NULISAseq, NULISA with next‐generation sequencing readout; NEFL, neurofilament light chain; Rho, Spearman's rank correlation coefficient ( rho ); Simoa, Single molecule array.
Article Snippet: Various automated and semi‐automated platforms, such as
Techniques: Comparison, Transformation Assay, Next-Generation Sequencing